Pair Name	Evodiamine, Gemcitabine
Disease Info	[ICD-11: 2B62.Z]	Tongue cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	RELA	hsa5970
In Vitro Model	CAL-27	Tongue adenosquamous carcinoma	Homo sapiens (Human)	CVCL_1107
	Tca8113	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_6851
In Vivo Model	CAL-27 cells (2×10⁶) were injected subcutaneously into the right armpit regions of nude mice.
Result	The results of this study showed that EVO may inhibit cancer cells by suppressing NF-κB activity, and in combination with GEM, it may increase the chemosensitivity of tongue squamous cancer cells, thereby improving the treatment response.